The use of proteins as bioreceptors for sensing/determining specific molecules is a natural progression in the applications of enzymes.  A few biosensors have been developed. Enzymes such as  diamine oxidase and formaldehyde dehydrogenase have been used to detect histamine and  formaldehyde respectively, particularly in the monitoring the quality of food products.   The signals can be detected by optical, amperometric or capacitance based transducers. To date, the usage of nanoscale receptors and transducers have become a priority. Currently our research is focused towards small peptides mimicking diamine oxidase and urate oxidase to determine uric acid levels in patients afflicted with gout. Such miniaturisation effort of the bioreceptors is critical to enhance sensitivity and robustness of the sensor as well as to attract widespread acceptance and utilization by the public.